Endocrine Abstracts

Background: Acromegaly is a neuroendocrine disease that occurs with slowly progressive symptoms, which leads to delayed diagnosis and the development of complications. Arthropathy is one of such complications, which is accompanied by severe pain and significantly worsens the quality of life. The main attention of researchers is devoted to the pathology of the hip, knee and hand joints. At the same time, the study of the shoulder, acromioclavicular, costovertebral joints in acr...

Objective: To study the effect of neurohormones kisspeptin and neurokinin B on the indices of calcium-phosphate and electrolyte metabolism in patients with neuroendocrine pathology.Material and Methods: Eighty-two female patients were included in this pilot study divided into 2 groups: ‘Cushing’s disease’ group (n=51) and ‘Acromegaly’ group (n=31). Median age was 33 years [27; 38] in ‘Cushing’s disease...

Background: ACTH-ectopic syndrome is a rare cause of endogenous hypercortisolism and may pose serious difficulties in topical diagnosis.Case description: Clinical features of hypercortisolism manifested at the age of 18 years (2012). A year later he was referred to an endocrinologist: ACTH 113 pg/ml (0–46), cortisol in 24-h urine 2915 μg/day (4.3–176), 1 mg DX test cortisol 1020 nmol/l, 8 mg DX test 764 nmol/l, intact pituitary MRI with co...

Introduction: Despite recent developments in biochemical, radiological and molecular techniques, a preoperative diagnosis of parathyroid carcinoma (PC) remains a difficult task. The main challenge of all studies in this area is a small number of cases based on retrospective data. The search for new blood biomarkers associated with PC could be important for early diagnosis and prognosis. Dysregulated microRNA (miRNA) levels are involved in tumorigenesis and may serve as diagnos...

Introduction: Hyponatremia after transnasal neurosurgery for pituitary adenomas is a serious and not so rare complication. It often occurs in a delayed manner after patient’s discharge and is a major cause of readmission. The pathogenesis of postneurosurgical hyponatremia is not clear yet.Aims: To study the role of posterior pituitary hormones (antidiuretic hormone (ADH) and apelin) and reaction of renin-aldosterone system (RAS) at hyponatremia mani...

Objectives: To evaluate predictors of permanent, transient and three-phase diabetes insipidus (DI) in patients undergoing endoscopic endonasal transsphenoidal surgery.Patients and methods: The study included 154 patients undergoing endoscopic endonasal transsphenoidal surgery (122 women and 32 men) age from 18 to 65 years (median 40 (31;52)). 73 patients with Cushing disease, 66 patients with acromegaly, four patients with prolactinomas, nine patients wi...

Introduction: Recent evidence suggests that the skeleton might be another affected organ in patients with type 2 diabetes mellitus (T2DM). This study evaluates the prevalence of low-traumatic vertebral and non-vertebral fractures and their risk factors in subjects with T2DM.Materials and methods: We invited outpatients with T2DM, who were under observation in a single outpatient clinic. The subjects were interviewed regarding the presence of low-traumati...

Introduction: FIPA- is a syndrome which includes pituitary adenomas with any kind of secretion in two or more members in a family in the absence of MEN or Carney complex; it also includes isolated family somatotropin syndrome (IFS).Aim: Molecular genetic study of a gene panel in FIPA patient.Materials and methods: Study included 1 family (2 men, 24 and 58 years) with pituitary adenomas with homogeneous secretion type — somatot...

Objective: To assess the sensitivity of granins – chromogranin A (CgA), secretogranin II (SgII), and secretoneurin (Sn) as biochemical and immunohistochemical markers of non-functioning pituitary adenomas (NFPAs):Methods: 50 patients with NFPAs were included in the study. Tissue samples were immunostained for pituitary hormones, Ki-67, αSU, CgA, SgII, and Sn. Furthermore, we have determined the levels of CgA, SgII in the serum and Sn in the pla...

Introduction: Several genetic syndromes are associated with familial pituitary adenomas. The penetrance of clinical manifestations of these syndromes is not ubiquitous and this might be the reason for the lack of detection of genetic mutations when only one or few genes are studied.Aim: Clinical characterisation and molecular genetic study of a panel with ten genes involved in formation of pituitary adenomas in familial setting.Mat...